PUBLICATIONS
Our publications
2026
Schwarz J, Hebel J, Dietz-Ziegler S, Rühle J, Lajqi T, Orlikowsky T, Poets CF, Gille C, Köstlin-Gille N. Depletion of Neonatal Neutrophilic Cells Worsens the Outcome of E. coli Sepsis in Newborn Mice. Eur J Immunol. 2026 Apr;56(4):e70171. doi: 10.1002/eji.70171.
2025
Chavero Vargas A, Köstlin-Gille N, Bauer R, Dietz-Ziegler S, Lokaj AS, Lutterbach S, Gille C, Lajqi T. Hypoxia Supports LPS-Driven Tolerance and Functional Activation in BV-2 Microglial Cells. Biology (Basel). 2025 Oct 28;14(11):1512. doi: 10.3390/biology14111512
Dietz-Ziegler S, Kewitz S, Kaiser G, Rühle J, Marmé A, Dalpke A, Cheaib B, Pauluschke-Fröhlich J, Henes M, Velic A, Pich A, Vollert A, Schaller M, Knab F, Lajqi T, Poets CF, Gille C, Köstlin-Gille N. Extracellular Vesicles Derived From the Feces of Pregnant Women Modulate T Cells Toward a Pregnancy-Supportive Phenotype In Vitro. Eur J Immunol. 2025 Sep;55(9):e70056. doi: 10.1002/eji.70056.
Glaser K, Rittenschober-Böhm J, Humberg A, Stichtenoth G, Butzer S, Mehler K, Kipfmüller F, Köstlin-Gille N, Gille C, Kick A, Dornis D, Henrich B, Farr A, Härtel C, Silwedel C. Study protocol: neonatal colonisation and infection with Ureaplasma in very immature preterm infants born <29 weeks of gestation (NEO-CONSCIOUS) – a prospective multicentre study assessing early life colonisation rates and potentially associated adverse outcomes. BMJ Open. 2025 Sep 2;15(9):e101442. doi: 10.1136/bmjopen-2025-101442.
Gille C, Jungwirth M, Pezer S, Dietz-Ziegler S, Köstlin-Gille N, Lajqi T. 4-Phenyl Butyric Acid (4-PBA) Suppresses Neutrophil Recruitment in a Murine Model of Acute Perinatal Inflammation. J Immunol Res. 2025 Jul 7;2025:2438058. doi: 10.1155/jimr/2438058
Fortmann I, Welp A, Hoffmann N, Faust K, Silwedel C, Retzmann J, Gembicki M, Köstlin-Gille N, Häfke A, Zemlin M, Marissen J, Bossung V, Soler Wenglein J, Scharf JL, Weichert J, Müller A, Ricklefs I, Rody A, Pirr S, Boutin S, Rupp J, Brinkmann F, Heideking M, Stichtenoth G, Göpel W, Herting E, Hanke K, Härtel C. Perinatal Antibiotic Exposure and Respiratory Outcomes in Children Born Preterm. JAMA Netw Open. 2025 May 1;8(5):e259647. doi: 10.1001/jamanetworkopen.2025.9647.
Faust K, Haug C, Pagel J, Jensen R, Stein A, Felderhoff-Müser U, Frommhold D, Brebach K, Wieg C, Hillebrand G, Naust B, Schmidt E, Koch L, Schmidtke S, Simon A, Zemlin M, Meyer S, Scholzen C, Köstlin-Gille N, Gille C, Longardt AC, Kärlin M, Lusga M, Göpel W, Krone M, Kampmeier S, Strecker F, Nurjadi D, König IR, Herting E, Rupp J, Härtel C. Hand hygiene versus additional non-sterile gloves and gowns use to prevent sepsis in preterm infants colonized with multi-resistant drug bacteria: the study protocol of the cluster-randomized, cross-over, non-inferiority BALTIC trial. Mol Cell Pediatr. 2025 Apr 7;12(1):4. doi: 10.1186/s40348-025-00192-2.
2024
Dietz S, Hebel J, Rühle J, Huff A, Eltzschig HK, Lajqi T, Poets CF, Gille C, Köstlin-Gille N. Impact of the adenosine receptor A2BR expressed on myeloid cells on immune regulation during pregnancy. Eur J Immunol. 2024 Dec;54(12):e2451149.doi: 10.1002/eji.202451149.
Rühle J, Schwarz J, Dietz S, Rückle X, Schoppmeier U, Lajqi T, Poets CF, Gille C, Köstlin-Gille N.
Impact of perinatal administration of probiotics on immune cell composition in neonatal mice. Pediatr Res. 2024 Dec;96(7):1645-1654. doi: 10.1038/s41390-024-03029-2.
Lajqi T, Köstlin-Gille N, Gille C.
Trained Innate Immunity in Pediatric Infectious Diseases. Pediatr Infect Dis J. 2024 Feb 1;43(2):e57-e59. doi: 10.1097/INF.0000000000004157.
2023
Schwarz J, Rühle J, Stephan K, Dietz S, Geißert J, Schoppmeier U, Frick JS, Hudalla H, Lajqi T, Poets CF, Gille C, Köstlin-Gille N.HIF-1α targeted deletion in myeloid cells decreases MDSC accumulation and alters microbiome in neonatal mice. Eur J Immunol. 2023 Jul;53(7):e2250144. doi: 10.1002/eji.202250144.
Köstlin-Gille N, Serna-Higuita LM, Bubser C, Arand J, Haag L, Schwarz CE, Heideking M, Poets CF, Gille C.
Early initiation of antibiotic therapy and short-term outcomes in preterm infants: a single-centre retrospective cohort analysis.Arch Dis Child Fetal Neonatal Ed. 2023 Nov;108(6):623-630. doi: 10.1136/archdischild-2022-325113.
Rühle J, Ginzel M, Dietz S, Schwarz J, Lajqi T, Beer-Hammer S, Poets CF, Gille C, Köstlin-Gille N.
Depletion of Ly6G-Expressing Neutrophilic Cells Leads to Altered Peripheral T-Cell Homeostasis and Thymic Development in Neonatal Mice. Int J Mol Sci. 2023 Apr 24;24(9):7763. doi: 10.3390/ijms24097763.
Dietz S, Molnar K, Riedel H, Haag L, Spring B, Orlikowsky TW, Poets CF, Gille C, Köstlin-Gille N. Expression of immune checkpoint molecules on adult and neonatal T-cells. Immunol Res. 2023 Apr;71(2):185-196. doi: 10.1007/s12026-022-09340-6.
Rückle X, Rühle J, Judd L, Hebel J, Dietz S, Poets CF, Gille C, Köstlin-Gille N. Different probiotic strains alter human cord blood monocyte responses. Pediatr Res. 2023 Jul;94(1):103-111. doi: 10.1038/s41390-022-02400-5.
Lajqi T, Köstlin-Gille N, Bauer R, Zarogiannis SG, Lajqi E, Ajeti V, Dietz S, Kranig SA, Rühle J, Demaj A, Hebel J, Bartosova M, Frommhold D, Hudalla H, Gille C.
Training vs. Tolerance: The Yin/Yang of the Innate Immune System. Biomedicines. 2023 Mar 2;11(3):766. doi: 10.3390/biomedicines11030766.
Schlegel C, Liu K, Spring B, Dietz S, Poets CF, Hudalla H, Lajqi T, Köstlin-Gille N, Gille C.
Decreased expression of hypoxia-inducible factor 1α (HIF-1α) in cord blood monocytes under anoxia. Pediatr Res. 2023 Mar;93(4):870-877. doi: 10.1038/s41390-022-02193-7.
2022
Bubser C, Liese J, Serna-Higuita LM, Müller A, Vochem M, Arand J, Karck U, Gross M, Poets CF, Härtel C, Zemlin M, Gille C, Köstlin-Gille N.
Impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants: a retrospective cohort analysis. Antimicrob Resist Infect Control. 2022 May 19;11(1):72. doi: 10.1186/s13756-022-01110-1.
Lajqi T, Köstlin-Gille N, Hillmer S, Braun M, Kranig SA, Dietz S, Krause C, Rühle J, Frommhold D, Pöschl J, Gille C, Hudalla H.
Gut Microbiota-Derived Small Extracellular Vesicles Endorse Memory-like Inflammatory Responses in Murine Neutrophils. Biomedicines. 2022 Feb 14;10(2):442. doi: 10.3390/biomedicines10020442.
Molnar K, Riedel H, Schwarz J, Dietz S, Spring B, Haag L, Poets CF, Gille C, Köstlin-Gille N.
Group B streptococci infection model shows decreased regulatory capacity of cord blood cells. Pediatr Res. 2022 Nov;92(5):1407-1416. doi: 10.1038/s41390-021-01880-1.
Dietz S, Schwarz J, Velic A, González-Menéndez I, Quintanilla-Martinez L, Casadei N, Marmé A, Poets CF, Gille C, Köstlin-Gille N. Human Leucocyte Antigen G and Murine Qa-2 Are Critical for Myeloid Derived Suppressor Cell Expansion and Activation and for Successful Pregnancy Outcome. Front Immunol. 2022 Jan 17;12:787468. doi: 10.3389/fimmu.2021.787468.
Köstlin-Gille N, Härtel C, Zemlin M, Müller A, Poets CF, Gille C.
Re: „Do Not Act Fast and Furious“. Pediatr Infect Dis J. 2022 Feb 1;41(2):e66-e67. doi: 10.1097/INF.0000000000003404.